- Title
- Overlap of irritable bowel syndrome and functional dyspepsia in the clinical setting: prevalence and risk factors
- Creator
- von Wulffen, Moritz; Talley, Nicholas J.; Hammer, Johann; McMaster, Jessica; Rich, Graeme; Shah, Ayesha; Koloski, Natasha; Kendall, Bradley J.; Jones, Mike; Holtmann, Gerald
- Relation
- Digestive Diseases and Sciences Vol. 64, Issue 2, p. 480-486
- Publisher Link
- http://dx.doi.org/10.1007/s10620-018-5343-6
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2019
- Description
- Background: According to Rome IV criteria, functional dyspepsia (FD) and irritable bowel syndrome (IBS) are distinct functional gastrointestinal disorders (FGID); however, overlap of these conditions is common in population-based studies, but clinical data are lacking. Aims: To determine the overlap of FD and IBS in the clinical setting and define risk factors for the overlap of FD/IBS. Methods: A total of 1127 consecutive gastroenterology outpatients of a tertiary center were recruited and symptoms assessed with a standardized validated questionnaire. Patients without evidence for structural or biochemical abnormalities as a cause of symptoms were then categorized based upon the symptom pattern as having FD, IBS or FD/IBS overlap. Additionally, this categorization was compared with the clinical diagnosis documented in the integrated electronic medical records system. Results: A total of 120 patients had a clinical diagnosis of a FGID. Based upon standardized assessment with a questionnaire, 64% of patients had FD/IBS overlap as compared to 23% based upon the routine clinical documentation. In patients with severe IBS or FD symptoms (defined as symptoms affecting quality of life), the likelihood of FD/IBS overlap was substantially increased (OR = 3.1; 95%CI 1.9-5.0) and (OR = 9.0; 95%CI 3.5-22.7), respectively. Thus, symptom severity for IBS- or FD symptoms were significantly higher for patients with FD/IBS overlap as compared to patients with FD or IBS alone (p all < 0.01). Age, gender and IBS-subtype were not associated with overlap. Conclusion: In the clinical setting, overlap of FD and IBS is the norm rather than the exception. FD/IBS overlap is associated with a more severe manifestation of a FGID.
- Subject
- functional gastrointestinal disorders; functional dyspepsia; irritable bowel syndrome; symptom severity
- Identifier
- http://hdl.handle.net/1959.13/1409983
- Identifier
- uon:36104
- Identifier
- ISSN:0163-2116
- Language
- eng
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